Dott. Gabriele Imbalzano
- NEUROSCIENZE
- Phd: 37th cycle
- Dottorato in Neuroscienze
- Matriculation number: 876031
- ORCID: orcid.org/0000-0002-4842-529X
Contacts
Phd thesis
My PhD project aims to evaluate the efficacy and tolerability of novel DBS stimulation paradigms in patients with disabling axial symptoms while treated with conventional high frequency stimulation of Subthalamic Nucleus.
Secondarily, we aim at evaluating the association of primary outcomes with data obtained from modern device-based medical measurements.
Research activities
My research activity is mainly focused on novel technologies for characterization and for new therapeutic strategies of Parkinson’s Disease.
1. Imbalzano G*, Rinaldi D*, Calandra-Buonaura G, Contin M, Amato F, Giannini G, Sambati L, Ledda C, Romagnolo A, Olmo G, Cortelli P, Zibetti M, Lopiano L, Artusi CA. How resistant are levodopa-resistant axial symptoms? Response of freezing, posture and voice to increasing levodopa intestinal infusion rates in Parkinson's disease. Eur J Neurol. 2022 Sep 12. doi: 10.1111/ene.15558. Epub ahead of print.
2. Ledda C, Montanaro E, Imbalzano G, Merola A, Bruno I, Artusi CA, Zibetti M, Rizzone MG, Bozzali M, Sobrero G, Vallelonga F, Maule S, Lopiano L, Romagnolo A. Burden of caregiving for cardiovascular dysautonomia in Parkinson's disease. Clin Auton Res. 2022 Aug 28.
3. Imbalzano G, Ledda C, Artusi CA, Romagnolo A, Montanaro E, Rizzone MG, Lopiano L, Zibetti M. SARS-CoV-2 vaccination, Parkinson's disease, and other movement disorders: case series and short literature review. Neurol Sci. 2022 Sep;43(9):5165-5168.
4. Ledda C, Artusi CA, Tribolo A, Rinaldi D, Imbalzano G, Lopiano L, Zibetti M. Time to onset and duration of botulinum toxin efficacy in movement disorders. J Neurol. 2022 Feb 3.
5. Rizzone MG, Mancini F, Artusi CA, Balestrino R, Bonvegna S, Fabbri M, Imbalzano G, Montanaro E, Romagnolo A, Zibetti M, Lopiano L. Efficacy of safinamide as add-on therapy after subthalamic nucleus deep brain stimulation in Parkinson disease. Neurol Sci. 2022 Jan 4.
6. F. Amato, L. Borzì, G. Olmo, C. A. Artusi, G. Imbalzano and L. Lopiano. Speech Impairment in Parkinson’s Disease: Acoustic Analysis of Unvoiced Consonants in Italian Native Speakers. IEEE Access, vol. 9, pp. 166370-166381, 2021
7. Piazza F, Bozzali M, Morana G, Ferrero B, Rizzone MG, Artusi CA, Parisi M, Robert A, Imbalzano G, Romagnolo A, Zibetti M, Lopiano L. Early reversible leukoencephalopathy and unilateral sixth cranial nerve palsy in mild COVID-19 infection. Neurol Sci. 2021 Sep 4:1–4.
8. Romagnolo A, Imbalzano G, Artusi CA, Balestrino R, Ledda C, De Rosa FG, Riccardini F, Montanaro E, Bozzali M, Rizzone MG, Zibetti M, Lopiano L. Neurological comorbidities and COVID-19-related case fatality: A cohort study. J Neurol Sci. 2021 Sep 15;428:117610.
9. Montanaro E, Romagnolo A, Fabbri M, Artusi CA, Imbalzano G, Rizzone MG, Lopiano L, Zibetti M. Association between sleep disorders and cognitive dysfunctions in non-demented patients with advanced Parkinson's disease. J Neurol. 2021 Jul 30.
10. Artusi CA, Sarro L, Imbalzano G, Fabbri M, Lopiano L. Safety and efficacy of tolcapone in Parkinson's disease: systematic review. Eur J Clin Pharmacol. 2021 Jun;77(6):817-829.
11. Montanaro E, Artusi CA, Rosano C, Boschetto C, Imbalzano G, Romagnolo A, Bozzali M, Rizzone MG, Zibetti M, Lopiano L. Anxiety, depression, and worries in advanced Parkinson disease during COVID-19 pandemic. Neurol Sci. 2021 May 4:1–8.
12. Artusi CA, Romagnolo A, Imbalzano G, Montanaro E, Zibetti M, Rizzone MG, Lopiano L.Deep brain stimulation outcomes in the malignant end of Parkinson's disease spectrum. Parkinsonism Relat Disord. 2021 May;86:5-9.
13. Merola A, Kobayashi N, Romagnolo A, Wright BA, Artusi CA, Imbalzano G, Litvan I, Van Laar AD, Bankiewicz K. Gene Therapy in Movement Disorders: A Systematic Review of Ongoing and Completed Clinical Trials. Front Neurol. 2021 Apr 6;12:648532.
14. Romagnolo A, Balestrino R, Imbalzano G, Ciccone G, Riccardini F, Artusi CA, Bozzali M, Ferrero B, Montalenti E, Montanaro E, Rizzone MG, Vaula G, Zibetti M, Lopiano L. Neurological comorbidity and severity of COVID-19. J Neurol. 2021 Mar;268(3):762-769.
15. Romagnolo A, Zibetti M, Lenzi M, Vighetti S, Pongmala C, Artusi CA, Montanaro E, Imbalzano G, Rizzone MG, Lopiano L. Low frequency subthalamic stimulation and event-related potentials in Parkinson disease. Parkinsonism Relat Disord. 2021 Jan;82:123-127.
16. Artusi CA, Romagnolo A, Imbalzano G, Marchet A, Zibetti M, Rizzone MG, Lopiano L. COVID-19 in Parkinson's disease: Report on prevalence and outcome. Parkinsonism Relat Disord. 2020 Nov;80:7-9.
17. Artusi CA, Imbalzano G, Sturchio A, Pilotto A, Montanaro E, Padovani A, Lopiano L, Maetzler W, Espay AJ. Implementation of Mobile Health Technologies in Clinical Trials of Movement Disorders: Underutilized Potential. Neurotherapeutics. 2020 Oct;17(4):1736-1746.
18. Imbalzano G, Artusi CA, Montanaro E, Romagnolo A, Rizzone MG, Lopiano L, Zibetti M. Tuning deep brain stimulation related depression by frequency modulation: A case report. Brain Stimul. 2020 Sep-Oct;13(5):1265-1267.
19. Fabbri M, Zibetti M, Calandra-Buonaura G, Contin M, Sambati L, Mohamed S, Romagnolo A, Berchialla P, Imbalzano G, Giannini G, Rizzone MG, Artusi CA, Cortelli P, Lopiano L. Levodopa/Carbidopa Intestinal Gel Long-Term Outcome in Parkinson's Disease: Focus on Dyskinesia. Mov Disord Clin Pract. 2020 Sep 18;7(8):930-939.
20. Fabbri M, Pongmala C, Artusi CA, Imbalzano G, Romagnolo A, Lopiano L, Zibetti M. Video analysis of long-term effects of levodopa-carbidopa intestinal gel on gait and posture in advanced Parkinson's disease. Neurol Sci. 2020 Jul;41(7):1927-1930.
21. Artusi CA, Balestrino R, Imbalzano G, Bortolani S, Montanaro E, Tuttobene S, Fabbri M, Zibetti M, Lopiano L. Beyond 10 years of levodopa intestinal infusion experience: Analysis of mortality and its predictors. Parkinsonism Relat Disord. 2020 Jul;76:98-103.
22. Artusi CA, Dwivedi A, Romagnolo A, Bortolani S, Marsili L, Imbalzano G, Sturchio A, Keeling EG, Zibetti M, Contarino MF, Fasano A, Tagliati M, Okun MS, Espay AJ, Lopiano L, Merola A. Differential response to pallidal deep brain stimulation among monogenic dystonias: systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2020 Apr;91(4):426-433.
G Imbalzano, E Montanaro, AF Olivetti, A Romagnolo, CA Artusi, MG Rizzone, M Zibetti, L Lopiano. Studio di confronto delle terapie di fase avanzata sui disturbi del sonno nella malattia di Parkinson. 7° Congresso Accademia LIMPE-DISMOV, Bologna 15-17 Dicembre 2021.
E Montanaro, CA Artusi, M Giacchero, G Imbalzano, A Romagnolo, MG Rizzone, M Zibetti, L Lopiano. L’impatto della stimolazione cerebrale profonda sul funzionamento socio-lavorativo nella malattia di Parkinson. 7° Congresso Accademia LIMPE-DISMOV, Bologna 15-17 Dicembre 2021.
A Romagnolo, E Montanaro, M Fabbri, CA Artusi, G Imbalzano, C Ledda, MG Rizzone, L Lopiano, M Zibetti. Disturbi del sonno e disturbi cognitivi in un’ampia coorte di pazienti affetti da malattia di Parkinson avanzata. Oral communication 7° Congresso Accademia LIMPE-DISMOV, Bologna 15-17 Dicembre 2021.
A Romagnolo, R Balestrino, G Imbalzano, G Ciccone, F. Riccardini, CA Artusi, M Bozzali, B Ferrero, E Montalenti, E Montanaro, M Rizzone, G Vaula, M Zibetti, L Lopiano. Neurological comorbidity affects Covid-19 severity. Poster 51° Congresso Società Italiana di Neurologia, Virtual Congress 28-30 Novembre 2020.
CA Artusi, G Imbalzano, A Sturchio, A Pilotto, E Montanaro, A Padovani, W Maetzler, A Espay, L Lopiano. Mhealth for movement disorders: analysis of strengths and pitfalls. Poster 51° Congresso Società Italiana di Neurologia, Virtual Congress 28-30 Novembre 2020.
G Imbalzano, A Romagnolo, M Zibetti, M Lenzi, S Vighetti, C Pongmala, C Artusi, E Montanaro, M Rizzone, L Lopiano. Effects of low frequency subthalamic stimulation on event-related potentials in Parkinson disease. Oral communication 51° Congresso Società Italiana di Neurologia, Virtual Congress 28-30 Novembre 2020.
Efficacy of Deep Brain Stimulation for dystonia: meta-analysis on the impact of genetics CA Artusi, AK Dwivedi, A Romagnolo, S Bortolani, L Marsili, G Imbalzano, A Sturchio, EG Keeling, M Zibetti, MF Contarino, A Fasano, M Tagliati, MS Okun, AJ Espay, L Lopiano, A Merola. Poster 6° Congresso Accademia LIMPE-DISMOV, Virtual Congress 16-18 Ottobre 2020.
CA Artusi, R Balestrino, G Imbalzano, S Bortolani, E Montanaro, A Romagnolo, M Rizzone, M Fabbri, M Zibetti, L Lopiano. Levodopa/carbidopa intestinal gel for Parkinson’s disease: mortality and its predictors. Poster 50° Congresso Società Italiana di Neurologia, Bologna 12-15 Ottobre 2019.
G Imbalzano, L Borzì, CA Artusi, A Romagnolo, M Fabbri, M Rizzone, M Zibetti, M Varrecchia, G Olmo, L Lopiano. Deep learning for Parkinson’s Disease: a case study on freezing of gait. Poster 50° Congresso Società Italiana di Neurologia, Bologna 12-15 Ottobre 2019.
G Imbalzano, L Borzì, CA Artusi, A Romagnolo, M Fabbri, M Rizzone, M Zibetti, M Varrecchia, G Olmo, L Lopiano. Detection of freezing of gait in Parkinson’s disease using smartphone. Poster 50° Congresso Società Italiana di Neurologia, Bologna 12-15 Ottobre 2019.
A Romagnolo, F Vallelonga, A Merola, CA Artusi, M Fabbri, G Imbalzano, M Zibetti, M Rizzone, S Maule, L Lopiano. Blood pressure circadian rhythm alterations in alphasynucleinopathies. Poster 50° Congresso Società Italiana di Neurologia, Bologna 12-15 Ottobre 2019.
CA Artusi, R Balestrino, G Imbalzano, S Bortolani, S Tuttobene, E Montanaro, M Zibetti, L Lopiano. Long-term levodopa-carbidopa intestinal infusion in Parkinson’sdisease: survival and mortality. International Congress of Parkinson’s Disease and Movement Disorders, Nice, France September 22-26, 2019
G Imbalzano, L Borzì, CA Artusi, A Romagnolo, M Fabbri, MG Rizzone, M Zibetti, S Sibile, M Varrecchia, G Olmo, L Lopiano. Rilevazione del freezing del cammino nella malattia di Parkinson tramite smartphone. Poster 5° Congresso Accademia LIMPE-DISMOV, Catania 22-24 Maggio 2019.
"Brain stimulation for neurological diseases" - Toolbox Course, 17th March and 7th April 2022
"Introduction to research methodology" - Toolbox Course, 4th, 11th, 18th and 25th February 2022
"Clinical, methodological and theoretical aspects of translational and cognitive neuroscience" - Toolbox Course, 20th January 2022
"Ethics of Research and Responsible research: an introduction" - Toolbox course, 3rd May 2022