Dott.ssa Eleonora Dallorto

NEUROSCIENZE
Phd: 37th cycle
Matriculation number: 821615
ORCID: orcid.org/0000-0003-4250-8702

Contacts

+39 3312910901
Chiama eleonora.dallorto
eleonora.dallorto@unito.it
Neuroscience Institute Cavalieri Ottolenghi (NICO)
Regione Gonzole, 10 - 10043 Orbassano (TO) - IT
Dept. Life Sciences and Systems Biology (DBIOS)
Via Accademia Albertina, 13 - 10123 Torino - IT
https://www.neurosciences.unito.it/do/studenti.pl/Show?821615
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Supervisor

Phd thesis

Molecular factors controlling mitochondrial function in postnatal neurogenesis and possible implication in cognitive disorders

The research project deals with the identification of molecular mechanisms crucial for mitochondrial function in postnatal neurogenic niches and their implication in cognitive disorders.
The project will focus on the mitochondrial dysfunction caused by deficiency of the transcriptional regulator Nr2f1 (also known as COUP-TFI) and will address the downstream target genes crucial for mitochondrial function and investigate its outcome on neuronal plasticity and function. Patients with Nr2f1 haploinsufficiency show mild to severe neurodevelopmental cognitive disorders, including intellectual disability, learning defects and language impairments. Through the combination of multiple methodologies ranging from gold-standard neuroanatomical techniques to advanced imaging tools as well as genome-wide approaches and mouse behavior, the project aims at unravelling the cellular and molecular mechanisms by which Nr2f1 controls mitochondrial function in neurons and how this is fundamental for proper cognitive behavior.

Tutors:

Prof. Silvia De Marchis

Prof. Michèle Studer

Dott.ssa Sara Bonzano

Research activities

Abstracts
Doctoral Educational Activities
Other Educational Activities
Publications
Organi

Dallorto E, Bonzano S, Hidisoglu E, Marcantoni A, Sassoè-Pognetto M, Studer M and De Marchis S. 20 h National Congress of the Italian Society of Neuroscience (SINS). 14-17 September, 2023 Turin (Italy). (selected oral presentation by E. Dallorto in the symposium “Mechanisms and therapies of metabolic and neurological disorders” ;Altered morphology of adult-born immature granule neurons and reduced synaptic inhibition in the hippocampal DG of a mouse modeling the neurodevelopmental disorder BBSOAS; .
Bonzano S. , Dallorto E., , Molineris IvanI., Michelon F., Crisci I., Gambarotta G., Neri F., Oliviero S. , Beckervordersandforth R., Lie Dieter C. , Peretto P., Bovetti S. , Studer M. , De Marchis S. 20 h National Congress of the Italian Society of Neuroscience (SINS). 14-17 September, 2023 Turin (Italy). (poster) “Nr2f1 shapes mitochondria in the mouse brain unraveling new insights into the neurodevelopmental disorder BBSOAS”.
Dallorto E, Bonzano S, Hidisoglu E, Molineris I, Gambarotta G, Marcantoni A, Studer M, and De Marchis S. JEDNs 2023, Journées de l’Ecole Doctorale de Nice - 15-17 May, 2023 Nice (France). ( poster) ;Nr2f1 haploinsufficiency leads to reduced inhibition of hippocampal DG neurons and mitochondrial dysfunction in the adult mouse brain.
Dallorto E, Bonzano S, Hidisoglu E, Pattaro A, Studer M, Marcantoni A and De Marchis S. "Nr2f1 haploinsufficiency affects immature granule neurons morphology and leads to an altered activation of neuronal ensembles within the adult mouse hippocampus". BRAYN Conference 2022 - Rome (Italy), 28-30 September 2022 (selecter poster)
Dallorto E, Bonzano S, Pattaro A, Studer M, De Marchis S. "Nr2f1 haploinsufficiency alters the morphology of adult-born neurons in the hippocampus of a mouse model of the neurodevelopmental disorder BBSOAS" FENS Forum 2022 - Paris (France), July 9-13 2022 (selected poster)
Dallorto E, Bonzano S, Pattaro A, Studer M, De Marchis S. "Morphological characterization of adult-born hippocampal neurons in a mouse model of the neurodevelopmental disorder BBSOAS". SINS National Meeting of PhD Students in Neuroscience 2022 - Brescia (Italy), June 11 2022 (selected poster)
Dallorto E, Bonzano S, Pattaro A, Studer M, De Marchis S. "Morphological characterization of adult-born hippocampal neurons in a mouse model of the neurodevelopmental disorder BBSOAS". Jacques Monod Conférence: Genetics, environment, signaling, & synaptic plasticity in developmental brain disorders: from bench to bedside - Roscoff (France), April 11-15 2022 (selected poster)
Dallorto E, Bonzano S, Pattaro A, Studer M, De Marchis S. "Morphological characterization of adult-born hippocampal neurons in a mouse model of the neurodevelopmental disorder BBSOAS". 94th National Congress of the Italian Society of Experimental Biology (SIBS) 2022 - Turin (Italy), April 06-09 2022 (selected poster)

2022

"Clinical, methodological and theoretical aspects of translational and cognitive neuroscience" A. Berti, A. Chiò, M. Giustetto, Broad Neuroscience Training - January 20th

"Corso di formazione generale in materia di igiene e sicurezza" e-learning - February 2022

"Introduction to Research Methodology" Daniele Romano - February 4th, 11th, 18th, 25th

"From neural cell excitability to brain circuit recording, visualization and manipulation"

In vitro analysis of neuronal activity by electrophysiological recordings; F. Tempia - February 1st 2022
Synaptic transmission in brain slices; F. Ferrini - March 8th 2022
Deciphering and manipulating synaptic transmission in brain circuits; G. Concina - March 15th 2022
Electrophysiological approaches to monitor and characterize neuronal activity in vivo; S. Zucca - March 22nd 2022
2-photon functional imaging of neural activity; S. Bovetti - March 29th 2022

"Innovative and experimental therapies in movement disorders"; Prof. Aristide Merola (The Ohio State University, USA) - Visiting Professorship:

Clinical and Pathological Basis of the most common Movement Disorders: Parkinsonisms, Dystonias, and Tremors. February 17th 2022
Observational and Experimental Studies for Therapeutic Interventions in Movement Disorders. March 10th 2022
Deep Brain Stimulation, Focused Ultrasound Ablation, and Gene Therapy. March 18th 2022

"How we reason"; M. Bucciarelli - Disciplinary training - 18th and 25th May 2022

"Ethics of research and responsible research"; D. Ovadia - Complementary training - 20th and 21st June 2022

"Motor neuron diseases: understanding the pathogenetic mechanisms to develop therapies" Workshop, 4th and 5th November 2022

“Public Engagement” course of the doctoral program of the PhD in Neuroscience, 18^th and 19^th November 2022

2021

"NICO NeuroWebinars" - Virtual conferences

"Winter school - Mitochondria in health, disease and aging", Université Côte d'Azur, Amphithéâtre le Galet, Hôpital Pasteur 2, Nice - from December 13th to 17th 2021

2022

"NICO NeuroWebinars" - Virtual conferences

"Elementi base per l'approccio dei ricercatori all'utilizzo degli animali ai fini scientifici" Corso FAD IZSLER, June 2022

"6^th Swiss Science Filmmaking Marathon Workshop", University of Zurich and Swiss Science Film Academy, from September 15th to17th 2022, Zurich (Switzerland)

"Formation A spécialisée à l'expérimentation animale (ex niveau 2) Attestation équivalente FELASA - Approches législative, éthique et pratique du rongeur du laboratoire" Université Côte d'Azur, from September 19th to 27th 2022

2023

“Corso di formazione pratico utilizzo animali da laboratorio” Charles River Laboratories Italia S.r.l, July 6th 2023

Bonzano S, Dallorto E, Molineris I, Michelon F, Crisci I, Gambarotta G, Neri F, Oliviero S, Beckervordersandforth R, Lie DC, Peretto P, Bovetti S, Studer M, De Marchis S. NR2F1 shapes mitochondria in the mouse brain, providing new insights into Bosch-Boonstra-Schaaf optic atrophy syndrome. Dis Model Mech. 2023 Jun 1;16(6):dmm049854. doi: 10.1242/dmm.049854. Epub 2023 Jun 26. PMID: 37260288; PMCID: PMC10309583.

Crisci I, Bonzano S, Nicolas Z, Dallorto E, Peretto P, Krezel W, De Marchis S. Tamoxifen exerts direct and microglia-mediated effects preventing neuroinflammatory changes in the adult mouse hippocampal neurogenic niche. Glia. 2024 Mar 21. doi: 10.1002/glia.24526. Epub ahead of print. PMID: 38515286.

Commissione Internazionalizzazione