Dott.ssa Claudia Ledda

NEUROSCIENZE
Phd: 39th cycle
Department of Neurosciences "Rita Levi Montalcini"
Matriculation number: 770208
ORCID: orcid.org/0000-0003-0839-932X

Contacts

Supervisor

Phd thesis

My PhD project aims to analyze the differential response to therapies of PD patients in advanced disease stages carrying GBA1 variants, considering relevant clinical, neurobehavioral, and neuropsychological issues, as well as specific genetic variants.

Research activities

My research activity is focused on studying the disease progression and the response to advanced therapies of PD patients carrying GBA1 variants.

Ledda C, Romagnolo A, Covolo A, Imbalzano G, Montanaro E, Rizzone MG, Artusi CA, Lopiano L, Zibetti M. Effects of dopaminergic therapy on sleep quality in fluctuating Parkinson's disease patients. J Neurol. 2024 Apr 12. doi: 10.1007/s00415-024-12351-y.

Avenali M, Zangaglia R, Cuconato G, Palmieri I, Albanese A, Artusi CA, Bozzali M, Calandra-Buonaura G, Cavallieri F, Cilia R, Cocco A, Cogiamanian F, Colucci F, Cortelli P, Di Fonzo A, Eleopra R, Giannini G, Imarisio A, Imbalzano G, Ledda C, Lopiano L, Malaguti MC, Mameli F, Minardi R, Mitrotti P, Monfrini E, Spagnolo F, Tassorelli C, Valentino F, Valzania F, Pacchetti C, Valente EM; PARKNET Study Group. Are patients with GBA Parkinson disease good candidates for deep brain stimulation? A longitudinal multicentric study on a large Italian cohort. J Neurol Neurosurg Psychiatry. 2023 Oct 25:jnnp-2023-332387. doi: 10.1136/jnnp-2023-332387.

Ledda C, Panero E, Dimanico U, Parisi M, Gandolfi M, Tinazzi M, Geroin C, Marchet F, Massazza G, Lopiano L, Artusi CA. Longitudinal Assessment of Botulinum Toxin Treatment for Lateral Trunk Flexion and Pisa Syndrome in Parkinson's Disease: Real-life, Long-Term Study. Toxins (Basel). 2023 Sep 11;15(9):566. doi: 10.3390/toxins15090566.

Rinaldi D, Imbalzano G, Galli S, Bianchini E, Ledda C, De Carolis L, Zibetti M, Lopiano L, Pontieri FE, Artusi CA. The impact of dysphagia in Parkinson's disease patients treated with levodopa/carbidopa intestinal gel. Parkinsonism Relat Disord. 2023 Mar 15;109:105368. doi: 10.1016/j.parkreldis.2023.105368. Epub ahead of print. PMID: 36933499.

Covolo A, Imbalzano G, Artusi CA, Montanaro E, Ledda C, Bozzali M, Rizzone MG, Zibetti M, Martone T, Lopiano L, Romagnolo A. 15-Year Subthalamic Deep Brain Stimulation outcome in a Parkinson's disease patient with Parkin gene mutation: a case report. Neurol Sci. 2023 Apr 10. doi: 10.1007/s10072-023-06789-7. Epub ahead of print. PMID: 37032388.

Artusi CA, Ledda C, Rinaldi D, Montanaro E, Romagnolo A, Imbalzano G, Rizzone MG, Zibetti M, Lopiano L, Bozzali M. Axial symptoms as main predictors of short-term subthalamic stimulation outcome in Parkinson's disease. J Neurol Sci. 2023 Sep 26;453:120818. doi: 10.1016/j.jns.2023.120818.

Ledda C, Artusi CA, Tribolo A, Rinaldi D, Imbalzano G, Lopiano L, Zibetti M. Time to onset and duration of botulinum toxin efficacy in movement disorders. J Neurol. 2022 Feb 3. doi: 10.1007/s00415-022-10995-2.

Ledda C, Montanaro E, Imbalzano G, Merola A, Bruno I, Artusi CA, Zibetti M, Rizzone MG, Bozzali M, Sobrero G, Vallelonga F, Maule S, Lopiano L, Romagnolo A. Burden of caregiving for cardiovascular dysautonomia in Parkinson's disease. Clin Auton Res. 2022 Aug 28. doi: 10.1007/s10286-022-00888-9.

Cartella SM, Bombaci A, Gallo G, Ledda C, Pengo M, Pignolo A, Pozzi FE, Spina E, Trinchillo A, Palermo G, Terranova C; on behaf of EduNet SIgN. Essential tremor and cognitive impairment: who, how, and why. Neurol Sci. 2022 Mar 31. doi: 10.1007/ s10072-022-06037-4. Epub ahead of print.

Imbalzano G, Ledda C, Artusi CA, et al. SARS-CoV-2 vaccination, Parkinson's disease, and other movement disorders: case series and short literature review [published online ahead of print, 2022 Jun 6]. Neurol Sci. 2022;1-4. doi:10.1007/s10072-022-06182-w

Imbalzano G, Rinaldi D, Calandra-Buonaura G, Contin M, Amato F, Giannini G, Sambati L, Ledda C, Romagnolo A, Olmo G, Cortelli P, Zibetti M, Lopiano L, Artusi CA. How resistant are levodopa-resistant axial symptoms? Response of freezing, posture and voice to increasing levodopa intestinal infusion rates in Parkinson's disease. Eur J Neurol. 2022 Sep 12. doi: 10.1111/ene.15558. Epub ahead of print. PMID: 36093563.

Balestrino R, Ledda C, Romagnolo A, Bozzali M, Giulietti G, Montanaro E, Rizzone M, Zibetti M, Artusi CA, Lopiano L. Motor and non-motor outcomes of subthalamic deep brain stimulation in a case of juvenile PARK-PINK1. Brain Stimul. 2021 May-Jun;14(3): 725-727.

Artusi CA, Romagnolo A, Ledda C, Zibetti M, Rizzone MG, Montanaro E, Bozzali M, Lopiano L. COVID-19 and Parkinson's Disease: What Do We Know So Far? J Parkinsons Dis. 2021;11(2):445-454.

Ledda C, Artusi CA, Montanaro E, Martone T, Zibetti M, Lopiano L. G325R GBA mutation in Parkinson's disease: Disease course and long-term DBS outcome. Brain Stimul. 2021 Sep- Oct;14(5):1169-1171.

Romagnolo A, Imbalzano G, Artusi CA, Balestrino R, Ledda C, De Rosa FG, Riccardini F, Montanaro E, Bozzali M, Rizzone MG, Zibetti M, Lopiano L. Neurological comorbidities and COVID-19-related case fatality: A cohort study. J Neurol Sci. 2021 Sep 15;428:117610.

11/04/2024 Oral presentation of following work: "Combined High- and Low-frequency Substantia Nigra and Subthalamic Nucleus Deep Brain Stimulation for Freezing of Gait in Parkinson’s disease: a cross-over randomized double-blind trial", 10° Congress of the Italian Society for Parkinson and movement disorders /LIMPE-DISMOV, Milan

23/10/2023 Presentation of the poster: “Lateral trunk deviation and Pisa Syndrome: botulinum toxin treatment in the short- and in the long-term”, 53° SIN Congress, Naples

05/05/2023 Presentation of the poster: “The impact of dopaminergic therapy on sleep quality of fluctuating Parkinson’s disease patients”, 9° Congress of the Italian Society for Parkinson and movement disorders /LIMPE-DISMOV, Padua

20/04/2023 Speech by the title: “Patient Profile: Parkinson”, Neuroyoung Conference, Venice

13/01/2023 Speech by the title: “The intrajejunal carbidopa-levodopa infusion and Apomorphine”, AINAT Conference 2023 Piedmont Region, Turin

04/12/2022 Presentation of the poster: “Presurgical axial symptoms and subthalamic Deep Brain Stimulation outcome in Parkinson’s disease”, 52° SIN Congress, Milan

17/09/2022 Presentation of the poster: “Caregiver’s burden in cardiovascular dysautonomia associated with Parkinson’s Disease”, International Congress of Parkinson's Disease and Movement Disorders, Madrid

17/11/2022 Presentation of the poster: “Risk factors associated with Parkinson’s Disease: a Case-Control Study”, 8° Congress of the Italian Society for Parkinson and movement disorders/LIMPE-DISMOV, Naples

16/12/2021 Presentation of the poster: “Time to onset and duration of botulinum toxin efficacy in movement disorders”, 7° Congress of the Italian Society for Parkinson and movement disorders/LIMPE-DISMOV, Bologna

05/10/2021 Presentation of the poster: “G325R GBA mutation in Parkinson’s disease: disease course and long-term DBS outcome”, 25th World Congress of Neurology, Rome, virtual event

"Clinical, methodological and theoretical aspects of translational and cognitive neuroscience" - Toolbox Course, 10^th January 2024

“Creatine Transporter Deficiency: the long journey to successful therapy”, Dr. Laura Baroncelli (Senior Researcher at Neuroscience Institute of CNR and IRCCS Fondazione Stella Maris, Pisa) – PhD seminar, 24^th January 2024

"Introduction to Research Methodology", Toolbox Course, 8^th-15^th-22^nd March 2024

03/05/2024 BLS-D Course, Turin, Croce Verde

8-9/02/2024 Course: “Tecnologie digitali per il monitoraggio da remoto dei disturbi del movimento”, Accademia Limpe-Dismov

25-16/01/2024 "Genomica: tecnologie avanzate", FISV, Università degli Studi di Milano, Milano

21-23/09/2023 MDS-ES School for young neurologists, Brno

01/04/2023-01/07/2023 Fellowship in clinical and molecular genetics of neurological disorders, IRRCS Fondazione Mondino, Pavia, Italy

18-20/03/2023 European Academy of Neurology Science School, Salzburg

2-3/03/2023 Course “Neuroimaging in parkinsonism: from diagnosis to therapeutical approaches”, Accademia Limpe-Dismov and Movement Disorder Society, Naples

09-11/02/2023 Residential course "Update on neurophysiological diagnostics and interventional therapies in movement disorders, 2nd edition”, Venice

18-21/11/2022 Movement Disorder Society 10^th advanced course on diagnosis and treatment of movement disorders, Naples

6-7/05/2022 and 17-18/06/2022 School of Movement Disorders, Accademia Limpe-Dismov, Genoa and Cagliari