Dott. Fausto Roveta
- NEUROSCIENZE
- Phd: 37th cycle
- Matriculation number: 735542
- ORCID: orcid.org/0000-0001-7230-7819
Contacts
- fausto.roveta@unito.it
- Via Cherasco 15, 10126, Torino
- https://www.neurosciences.unito.it/do/studenti.pl/Show?735542
- VCard contacts
- QRcode contacts
Supervisor
Innocenzo RaineroPhd thesis
Investigating synaptic and neuroinflammation biomarkers in the Alzheimer’s disease continuum
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by complex clinical phenotypes and neuropathological changes. Neuroinflammation and synaptic disruption are emerging as key contributors to AD pathogenesis. This prospective interventional study aims to elucidate the role of these processes in neurodegeneration and predict clinical progression. We will enroll a cohort of 60 subjects diagnosed with mild cognitive impairment (MCI) due to AD. The diagnosis will adhere to 2018 National Institute of Aging and Alzheimer’s Association criteria and include CSF biomarker analysis. Neuroinflammatory markers (GFAP, sTREM2) and synaptic degeneration markers (SNAP-25, GAP-43) will be measured in CSF. Additionally, FDG-PET scans will assess regional brain glucose metabolism. Correlation analyses will reveal associations between biomarker profiles and their contribute to determining neuronal dysfunction, as measured by quantitative FDG-PET. Clinical and neuropsychological longitudinal assessments at 6 and 12 months will investigate biomarker-based predictions of cognitive trajectory. This study will enhance our understanding of neuroinflammation and synaptic disruption in AD and the results may facilitate improvement of diagnostic and prognostic applications of these biomarkers. As disease-modifying therapies emerge, profiling patients based on diverse disease aspects becomes crucial. The findings could contribute to precision medicine strategies for AD. In conclusion, this study seeks to provide valuable insights into the complex interplay of neuroinflammation and synaptic dysfunction in AD. By comprehensively investigating these processes and predicting disease progression, this research aims to contribute to the advancement of AD diagnosis and treatment strategies.
Research activities
- Research Area
- Publications
- Contributes at Scientific Congresses
- Doctoral Educational Activities
- Other Activities
My research activity is mainly focused on Alzheimer's disease and related dementias as well as other neurodegenerative diseases. In particular, my PhD project aims to identify valid disease-specific biomarkers of synaptic injury and dysfunction, able to predict the conversion from prodromal Alzheimer's disease to dementia. My interests are also directed towards the study of primary headaches, including migraine and cluster headaches.
Boschi S, Roveta F, Grassini A, et al. Aβ42 as a Biomarker of Alzheimer's Disease: Is Saliva a Viable Alternative to Cerebrospinal Fluid?. Brain Sci. 2022;12(12):1729. Published 2022 Dec 17. doi:10.3390/brainsci12121729
Marcinnò A, Gallo E, Roveta F, et al. Decreased resistin plasmatic concentrations in patients with Alzheimer's disease: A case-control study. Heliyon. 2022;8(11):e11738. Published 2022 Nov 21. doi:10.1016/j.heliyon.2022.e11738
Cermelli A, Roveta F, Giorgis L, et al. Is headache a risk factor for dementia? A systematic review and meta-analysis [published online ahead of print, 2023 Sep 18]. Neurol Sci. 2023;10.1007/s10072-023-07069-0. doi:10.1007/s10072-023-07069-0
Roveta F, Grassini A, Marcinnò A, Rubino E, Rainero I. The political discourse on Alzheimer's disease and related dementias: a Twitter content analysis. Neurol Sci. 2023;44(9):3319-3320. doi:10.1007/s10072-023-06799-5
Rubino E, Marcinnò A, Grassini A, et al. Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks. Int J Mol Sci. 2022;24(1):657. Published 2022 Dec 30. doi:10.3390/ijms24010657
Rubino E, Boschi S, Roveta F, et al. Investigating p62 Concentrations in Cerebrospinal Fluid of Patients with Dementia: A Potential Autophagy Biomarker In Vivo?. Brain Sci. 2022;12(10):1414. Published 2022 Oct 20. doi:10.3390/brainsci12101414
Roveta F, Marcinnò A, Grassini A, et al. A Novel PSEN1 Variant Leading to Posterior Cortical Atrophy: A Case Report. J Alzheimers Dis Rep. 2023;7(1):469-473. Published 2023 May 31. doi:10.3233/ADR230023
Roveta F, Cermelli A, Boschi S, et al. Synaptic Proteins as Fluid Biomarkers in Alzheimer's Disease: A Systematic Review and Meta-Analysis. J Alzheimers Dis. 2022;90(4):1381-1393. doi:10.3233/JAD-220515
Bellenguez C, Küçükali F, Jansen IE, et al. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nat Genet. 2022;54(4):412-436. doi:10.1038/s41588-022-01024-z
Rubino E, Boschi S, Giorgio E, et al. Analysis of the DNA methylation pattern of the promoter region of calcitonin gene-related peptide 1 gene in patients with episodic migraine: An exploratory case-control study. Neurobiol Pain. 2022;11:100089. Published 2022 Apr 2. doi:10.1016/j.ynpai.2022.100089
Roveta F, Marcinnò A, Cremascoli R, et al. Increased orexin A concentrations in cerebrospinal fluid of patients with behavioural variant frontotemporal dementia. Neurol Sci. 2022;43(1):313-317. doi:10.1007/s10072-021-05250-x
Cremascoli R, Sparasci D, Giusti G, et al. Effects of Circadian Phase Tailored Light Therapy on Sleep, Mood, and Cognition in Alzheimer's Disease: Preliminary Findings in a Pivotal Study. Front Physiol. 2022;12:755322. Published 2022 Jan 6. doi:10.3389/fphys.2021.755322
Franchino F, Morra I, Forni M, et al. Medulloblastoma in adults: an analysis of clinico-pathological, molecular and treatment factors [published online ahead of print, 2021 Nov 11]. J Neurosurg Sci. 2021;10.23736/S0390-5616.21.05548-X. doi:10.23736/S0390-5616.21.05548-X
de Rojas I, Moreno-Grau S, Tesi N, et al. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat Commun. 2021;12(1):3417. Published 2021 Jun 7. doi:10.1038/s41467-021-22491-8
Gentile E, Delussi M, Abagnale C, et al. Migraine during COVID-19: Data from Second Wave Pandemic in an Italian Cohort. Brain Sci. 2021;11(4):482. Published 2021 Apr 10. doi:10.3390/brainsci11040482
Grassini A, Marcinnò A, Roveta F, et al. Impact of COVID-19 on chronic migraine treated with erenumab: a case report. Neurol Sci. 2021;42(8):3079-3081. doi:10.1007/s10072-021-05329-5
Zucca M, Isella V, Lorenzo RD, et al. Being the Family Caregiver of a Patient With Dementia During the Coronavirus Disease 2019 Lockdown. Front Aging Neurosci. 2021;13:653533. Published 2021 Apr 20. doi:10.3389/fnagi.2021.653533
Delussi M, Gentile E, Coppola G, et al. Investigating the Effects of COVID-19 Quarantine in Migraine: An Observational Cross-Sectional Study From the Italian National Headache Registry (RICe). Front Neurol. 2020;11:597881. Published 2020 Nov 10. doi:10.3389/fneur.2020.597881
Rainero I, Bruni AC, Marra C, et al. The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey. Front Aging Neurosci. 2021;12:625781. Published 2021 Jan 18. doi:10.3389/fnagi.2020.625781
Cagnin A, Di Lorenzo R, Marra C, et al. Behavioral and Psychological Effects of Coronavirus Disease-19 Quarantine in Patients With Dementia. Front Psychiatry. 2020;11:578015. Published 2020 Sep 9. doi:10.3389/fpsyt.2020.578015
Rainero I, Roveta F, Vacca A, Noviello C, Rubino E. Migraine pathways and the identification of novel therapeutic targets. Expert Opin Ther Targets. 2020;24(3):245-253. doi:10.1080/14728222.2020.1728255
Zucca M, Rubino E, Vacca A, et al. Metacognitive impairment in patients with episodic and chronic migraine. J Clin Neurosci. 2020;72:119-123. doi:10.1016/j.jocn.2019.12.048
Rainero I, Vacca A, Roveta F, Govone F, Gai A, Rubino E. Targeting MTHFR for the treatment of migraines. Expert Opin Ther Targets. 2019;23(1):29-37. doi:10.1080/14728222.2019.1549544
Cermelli, A., Lombardo, C., Boschi, S., Ferrandes, F., Grassini, A., Marcinnò, A., Roveta, F., Rubino, E., Rainero, I. The Clock Drawing Test in the A/T/N classification scheme framework: a cross-sectional analysis. XVII Convegno Nazionale SINDEM, 13-15 Ottobre 2022, Firenze.
S. Boschi, E. Ficiara, E. Rubino, F. Roveta, A. Grassini, F. Ferrandes, A. Marcinno', A. Cermelli, C. Guiot, I. Rainero. Investigating the role of iron in the neurotoxicity of Alzheimer’s disease. XVII Convegno Nazionale SINDEM, 13-15 Ottobre 2022, Firenze.
F. Roveta, A. Cermelli, S. Boschi, F. Ferrandes, A. Grassini, A. Marcinno', M. Spina, E. Rubino, I. Rainero. Synaptic proteins as fluid biomarkers in Alzheimer’s disease: a systematic review and meta-analysis. XVII Convegno Nazionale SINDEM, 13-15 Ottobre 2022, Firenze.
M. Caglio, S. Vighetti, F. Roveta, A. Cermelli, M. Zucca, P. De Martino, A. Marcinno', A. Grassini, F. Ferrandes, S. Boschi, E. Rubino, M. Molo, I. Rainero. Tolerability of tRNS in the cognitive rehabilitation treatment of patients with FTD (PPA). XVII Convegno Nazionale SINDEM, 13-15 Ottobre 2022, Firenze.
F. Roveta, A. Grassini, S. Boschi, F. Ferrandes, A. Marcinno', A. Cermelli, E. Rubino, I. Rainero. The political discourse on Alzheimer's disease and related dementias: a Twitter content analysis. 52° Congresso SIN, 3-6 Dicembre 2022, Milano.
F. Roveta, A. Cermelli, S. Boschi, F. Ferrandes, A. Grassini, A. Marcinno', M. Spina, E. Rubino, I. Rainero. Investigating the role of synaptic proteins in Alzheimer’s disease: a systematic review and meta-analysis. 52° Congresso SIN, 3-6 Dicembre 2022, Milano.
F. Roveta, S. Boschi, F. Pratico', E. Ficiara', E. Rubino, A. Grassini, F. Ferrandes, A. Marcinno', A. Cermelli, C. Guiot, I. Rainero. Role of iron metabolism in Alzheimer’s disease and other dementias: an exploratory study. 52° Congresso SIN, 3-6 Dicembre 2022, Milano.
A. Grassini, A. Cermelli, C. Lombardo, F. Ferrandes, A. Marcinno, E. Piella, F. Roveta, S. Boschi, A. Lesca, M. Zotta, E. Rubino, A.C. Bruni, I. Rainero. Expanding the neuropsychological and clinical knowledge on Spinocerebellar Ataxia 17: a case report. 52° Congresso SIN, 3-6 Dicembre 2022, Milano.
Cermelli, A., Lombardo, C., Roveta, F., Marcinnò, A., Boschi, S., Grassini, A., Ferrandes, F., Piella, E., Rubino, E., Rainero, I. Comparative Analysis of Clock Drawing Test Performance in Alzheimer's Disease and Suspected Non-Alzheimer's Pathophysiology Patients: A Cross-Sectional Study. SINS National Meeting of PhD Students in Neuroscience, 14 September 2023, Turin.
A Cermelli, C Carbone, M Caglio, A Marcinnò, F Roveta, A Vacca, E Rubino, I Rainero. Safety and efficacy of transcranial direct current stimulation on patients with Alzheimer’s disease, frontotemporal dementia and Lewy body dementia: systematic review and meta-analysis. Poster XV National Congress SINDEM, Virtual Edition, Firenze 2020.
Roveta F, Marcinnò A, Gallo E, Zucca M, Cermelli A, Cremascoli R, Priano L, Cattaldo S, Boschi S, Rubino E, Mauro A, Rainero I. Increased orexin-A concentrations in cerebrospinal fluid of patients with behavioural variant-frontotemporal dementia. Poster XV National Congress SINDEM, Virtual Edition, Firenze 2020.
Roveta F, Anti-CGRP/R mAbs post Botulinum toxin type A. Oral Communication 15/02/2020 (SISC) “Symposium Florence Headache & CGRP” – Firenze.
Roveta F, Rubino E, Vacca A, Boschi S, Zucca M, Parisi M, Gallo E, Marcinnò A, Imperiale D, Rainero I. Progressive non-fluent aphasia with progranulin (GRN) F86SFX170 gene mutation: a case report. Poster L National Congress SIN, Bologna 2019.
Zucca M, Canale A, Rubino E, Montuschi C, Vacca A, De Martino P, Roveta F, Giordana MT, Albera R, Rainero I. Quality of life and cognitive benefits of cochlear implant in elderly deaf patients: a 1-year follow-up. Poster L National Congress SIN, Bologna 2019.
Boschi S, Ficiarà E, Ansari S, Ruffinatti F, Rubino E, Roveta F, Abollino O, Parisi M, Guiot C, Rainero I. Iron content in cerebrospinal talian novel biomarker for early diagnosis of Alzheimer disease. Poster L National Congress SIN, Bologna 2019.
Zucca M, Rubino R, Vacca A, Roveta F, De Martino P, Caglio M, Carbone C, Giordana M, Rainero I. Changing in talian caregivers’ needs of patients with neurodegenerative disorders during the progression of the disease. Poster L National Congress SIN, Bologna 2019.
E Rubino, A Vacca, C Noviello, F Roveta, S Gentile, S Boschi, I Rainero. Gender differences in the clinical features of cluster headache: results from a single-center study. Poster XXXIII National Congress SISC, Napoli 2019.
E Rubino, S Boschi, E Giorgio, A Vacca, F Roveta, S Gentile, L Pinessi, MT Giordana, I Rainero. DNA methylation analysis of calcitonin gene–related peptide gene in patients with migraine. Poster XXXIII National Congress SISC, Napoli 2019.
M Zucca, E Rubino, A Vacca, E Gallo, F Roveta, P De Martino, M Giordana, I Rainero. The carers’ needs assessment for Dementia: a new clinical tool for the assessment of needs and possible intervention strategies in caregivers of patients with dementia. Poster XIV National Congress SINDEM, Firenze 2019.
Pradotto L, Mencarelli M, Roveta F, Vigna L, Cattaldo S, Di Blasio A, Mauro A. (2018). Expanding the spectrum of the clinical manifestations of the Glu51Gly TTR gene mutation. Poster XLIX National Congress SIN Roma, 2018.
"Neuromuscolar disorders in the era of advanced therapies: new perspectives for clinical and transitional research" - Advanced Course, 20th and 22nd September 2023
"Brain stimulation for neurological diseases" - Toolbox Course, 17th March and 7th April 2022
"Introduction to research methodology" - Toolbox Course, 4th, 11th, 18th and 25th February 2022
"Clinical, methodological and theoretical aspects of translational and cognitive neuroscience" - Toolbox Course, 20th January 2022
"Ethics of Research and Responsible research: an introduction" - Toolbox course, 3rd May 2022
"Terza Missione"
Update report on the diagnosis and treatment of Alzheimer's disease for the general public -World Alzheimer's Day 22nd September 2023, AIMA Biella