PhD in Neuroscience

Contacts

Supervisor

Curriculum vitae

Phd thesis

Towards a personalized medicine in amyotrophic lateral sclerosis (ALS) by a patient-tailored genetic/biomarker combined approach

ALS is characterized by significant phenotypic variability, leading to notable differences among patients in terms of age of onset, gender prevalence, progression rate, burden, and prognosis. The clinical manifestations also exhibit considerable variability, primarily influenced by factors such as age, site of onset, involvement of cognitive/behavioral functions, and genetic predisposition.

In this project, my intention is to conduct a comprehensive evaluation of biological, neuroradiological, genetic, and neuropsychological markers in a cohort of ALS patients. The primary objective is to achieve a thorough characterization of the patients' phenotypes in a detailed, effective, and comprehensive manner. The data collected will be subjected to analysis using artificial intelligence techniques, aiming to reveal meaningful associations and insights.

Additionally, this project will pursue collateral objectives, including the evaluation of potential correlations between biomarker levels and neuropsychological/neuroradiological markers, longitudinal trends of neuroradiological and biomarkers, along with their potential correlations with changes in clinical phenotype observed during subsequent follow-up. Furthermore, this project aims to identify possible biological and genetic factors underlying the different ALS phenotypes.

Research activities

• E. Matteoni, A. Calvo, C. Moglia, M. Grassano, M. Barberis, M. Brunetti, A. Lomartire, G. De Marco, A. Chio', A. Canosa. “A novel intronic FUS mutation in a familial ALS case: effects of protein expression in peripheral blood mononuclear cells”, Italian Society of Neurology, virtual Congress, 28/11/2020. Poster presentation

• Matteoni E., Manera U., Iazzolino B., Peotta L., Canosa A., Vasta R., Palumbo F., Torrieri MC., Grassano M., Moglia C., Calvo A., Chiò A. “Anxiety predicts survival more than depression in Amyotrophic Lateral Sclerosis”, the European Network for the Cure of ALS (ENCALS), virtual Congress, 12/05/2021. Poster presentation

• E. Matteoni, S. Cabras, F. Palumbo, S. Gallone, F. Casale, P. Salamone, G. De Marco, G. Fuda, U. Manera, M. Grassano, A. Dardis, A. Calvo, A. Chiò, C. Moglia, A. Canosa, R. Vasta. “Niemann Pick disease type C: two variants of unknown significance in a patient with an atypical presentation”, European Academy of Neurology (EAN), Vienna, Austria. 27/06/2022 E-poster presentation.

• Enrico Matteoni, U. Manera, M. Zotta, M. Cavallini, S. Cabras, L. Peotta, F. Palumbo, S. Gallone, C. Moglia, A. Calvo, A. Chiò, A. Canosa. “Bilateral Prefrontal Hypermetabolism at Brain ¹⁸FDG-PET in a Case of Behavioral Variant of Frontotemporal Dementia”, Italian Society of Neurology, Milan, Italy 03/12/2022. Poster presentation 

• E. Matteoni, E. Grange, R. Di Giovanni, C. Solaro. “Post-stroke depression: a retrospective observational study in an Italian rehabilitation ward”, Italian Society of Neurology, Milan, Italy, 04/12/2022. Oral presentation

• E. Matteoni, Umberto Manera, Fabiola De Marchi, Paolo Cugnasco, Cristina Moglia, Antonio Canosa, Maurizio Grassano, Rosario Vasta, Giuseppe Fuda, Giulia Marchese, Paolina Salamone, Federico Casale, Letizia Mazzini, Andrea Calvo, Adriano Chiò. “Peripheral immune signatures in ALS: a population-based study”, the European Network for the Cure of ALS (ENCALS), Barcelona, Spain, 13/07/2023. Poster presentation