Dott.ssa Amishaben Ramanbhai Parmar

NEUROSCIENZE
Phd: 38th cycle
Department of Neurosciences "Rita Levi Montalcini"
Matriculation number: 1041302

Phd thesis

Dorsal root ganglia (DRG) neurons can grow up to a meter long in the adult human. Upon injury, peripheral axons regenerate but mostly functional recovery is poor due to a slower growth rate and misrouting target, this as a consequence provokes neuropathic pain. How can we modulate growth and thus avoid aberrant regeneration and inaccurate target reinnervation? Previously, we observed that importin a3 protein modulates the pain response via c-FOS transcription factor. So far, it is unknown if the reduction of importin a3 and/or influence of neurotrophins (Neurotrophin-3, Nerve Growth Factor) modulate axonal growth and survival after injury. Here, we are investigating how the injury impacts sensory neuronal growth and survival using in vitro injury model in wildtype and importin a3 mutant sensory neurons with or without neurotrophic factor treatment. Our high-throughput imaging and blinded quantification approach allow us to obtain unbiased results. Future prospects are to provide insights on signaling mechanisms of regulation between axonal growth dynamics and pain perception in vivo.

Research activities

2023

Neuromuscular disorders in the era of advanced therapies: new perspectives for clinical and translational research - Tiziana Enrica Mongini, September 20^thand 22^nd
Neuropsychophysiology of the placebo and nocebo phenomena - Martina Amanzio, June 9^th, 16^th, 23^rd
Toolbox course: Ethics of research and responsible research: an introduction - Daniela Ovadia, March 13^th -14^th
Toolbox course: Introduction to research methodology - Daniele Romano, February 10 th, 17 th, 24^th
Toolbox course: Clinical, methodological and theoretical aspects of translational and cognitive neuroscience - Maurizio Giustetto, Annamaria Berti, Adriano Chiò, January 11^th

2022

Welcome meeting XXXVIII cycle and 1st Enrica Marzola award ceremony, December 7^th
Toolbox course: Public engagement and outreach, November 18^th-19^th

2023

Utrecht Summer school on Neural Circuit Development and Plasticity, Utrecht, The Netherlands, July 10^th- 14^th
NICO NeuroWebinar: Mike Fainzilber (Weizmann Institute of Science, Israel) - "Neuronal Injury Signaling: SINEs of Growth?", July 7^th
NICO NeuroWebinar: Samuele Negro (University of Padova, Italy) - "CXCR4: a new target to boost peripheral nerve regeneration", February 10^th
NICO NeuroWebinar: Indrek Koppel (Tallinn University of Technology, Estonia) - "Cell type-specific omics of neurons and glia", January 27^th
General Training Course on Health and Safety for Workers (art. 37 of Legislative Decree 81/08), University of Turin, January 25^th

2022

NICO NeuroWebinar (Progress report): Marta Ribodino (NICO, Turin) - "Neuroanatomical and functional integration of human striatal neurons into a rodent model of Huntington Disease", December 21^st
NICO NeuroWebinar: Marco Terenzio (OIST, Okinawa) - "Dynein Roadblock 1 mediates axonal transport and degradation of FMRP1 in sensory neurons", November 25^th
Training 2022: BIOLOGY AND MANAGEMENT OF LABORATORY ANIMALS, MODULES 3.1, 4, 5, 6.1, 7. DM 5 AUGUST 2021 RODENTS AND LAGOMORPHS - 1^ Edition, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, November 24^th
Training 2022: NATIONAL LEGISLATION AND ETHICS LEVEL 1, MODULES 1 AND 2, DM 5 AUGUST 2021 - Unique Edition, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, November 24^th
NICO NeuroWebinar: Bianca Silva (CNR, Humanitas) -"Brain circuits for fear attenuation", November 14^th

2023

Poster at SINS 2023 National Congress, September 14^th– 17^th, Turin, Italy
Poster at SINS National Meeting of PhD Students in Neuroscience, September 14^th, Turin, Italy
Poster at Gordon Research Conference: Neurotrophic Mechanisms in Health and Disease. May 28^th – June 2^nd, Newport (RI), United States

2022

Motor Neuron Diseases: understanding the pathogenetic mechanisms to develop therapies (2^nd Edition). November 4^th– 5^th, Turin, Italy

Parmar; Head L.; Dotta S.; Musso G.; By Cunto F.; Rother F.; Bader M.; Marvaldi L. The role of importin a3 in sensory neurons upon in vitro injury, SINS 2023 National Congress, September 14^th – 17^th, Turin, Italy
Head L.; Parmar A.; Dotta S.; Musso G.; Rother F.; Bader M.; Marvaldi L. Importin α3 contribution to the pain transduction pathway, SINS 2023 National Congress, September 14^th – 17^th, Turin, Italy
Parmar; Head L.; Dotta S.; Musso G.; By Cunto F.; Rother F.; Bader M.; Marvaldi L. The role of importin a3 in sensory neurons upon in vitro injury, SINS National Meeting of PhD Students in Neuroscience, September 14^th, Turin, Italy
Parmar; Head L.; Dotta S.; Musso G.; By Cunto F.; Rother F.; Bader M.; Marvaldi L. The role of importin a3 in sensory neurons upon in vitro injury, Gordon Research Conference on Neurotrophic Mechanisms in Health and Disease, May 28^th – June 2^nd, Newport (RI), United States
Head L.; Parmar A.; Dotta S.; Musso G.; Rother F.; Bader M.; Marvaldi L. Importin α3 contribution to the pain transduction pathway, Gordon Research Conference on Neurotrophic Mechanisms in Health and Disease, May 28^th – June 2^nd, Newport (RI), United States
Dotta S.; Musso G.; Parmar A.; Head L.; Rother F.; Bader M.; Marvaldi L. A comparison of young and aged neuronal growth in importin α3 deficient mice, Gordon Research Conference on Neurotrophic Mechanisms in Health and Disease, May 28^th – June 2^nd, Newport (RI), United States